Nature Neuroscience

Placental signaling influences cerebellum development

Nature Neuroscience, Published online: 13 September 2021; doi:10.1038/s41593-021-00918-1

Placental allopregnanolone affects oligodendrocyte differentiation and myelination in the developing cerebellum. Male mice deprived of allopregnanolone in utero show impaired sociability and communication in later life; their female littermates are unaffected. Allopregnanolone replacement restores normal myelination and behavior.

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